In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 167479-01-8, name is tert-Butyl (3-iodopropyl)carbamate belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. SDS of cas: 167479-01-8
Part C A solution of 4-amino-2-ethoxymethyl-1-isopropylamino-1H-imidazo[4,5-c]quinolin-7-ol (0.11 g, 0.35 mmol) in 10 ML of N,N-dimethylformamide was placed under an atmosphere of nitrogen and was treated with cesium carbonate (0.23 g, 0.70 mmol).After 5 min of stirring the mixture was treated with tert-butyl 3-iodopropylcarbamate (0.12 g, 0.35 mmol) and heated to 65 C. After 60 h, the reaction mixture was cooled to ambient temperature and then poured into 100 ML of ice water which resulted in a cloudy suspension.The mixture was extracted with CHCl3 (5*25 ML).The combined organic extracts were then washed with brine (50 ML), dried over Na2SO4, filtered and concentrated under reduced pressure to yield a tan oil.Chromatography (95:5 CHCl3:(80:18:2 CHCl3:MeOH:NH4OH) gradient to 1:1 gave 0.040 g of [3-(4-amino-2-ethoxymethyl-1-isopropylamino-1H-imidazo[4,5-c]quinolin-7-yloxy)propyl] tert-butyl carbamate as a light tan solid. LC/MS (APCI) m/z 473 (M+H)+.
The synthetic route of 167479-01-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; 3M Innovative Properties Company; US2004/176367; (2004); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com