At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1,2-Dichloro-4-iodobenzene, and friends who are interested can also refer to it.
Electric Literature of 20555-91-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 20555-91-3 name is 1,2-Dichloro-4-iodobenzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Example HI; Preparation of l -(3,4-dichlorophenyl)-bicvclo[3 1 0]hexan-2-amines and 1-C3.4- dichlorophenyl)-bicvclo[3 1 0]hexan-3 -amines using Reaction Schemes 1 and 2A. Synthesis of 3-(3,4-diehlorophenyl)prop-2-vn-l-ol EPO Bis(t?phenylphosphine)palladium(II) chlonde (120 mg, 0 171 mmol) was added to a stirred solution of propargyl alcohol (5 24 g, 93 4 mmol, 1 02 eq), 1 -iodo- 3,4-dichlorobenzene (25 0 g, 91 6 mmol, 1 eq), t?ethylamine (18 5 g, 183 2 mmol, 2 eq), and copper iodide (60 mg, 0 32 mmol) in THF (50 mL) The mixture was stirred at 350C for 12 h under a nitrogen atmosphere The mixture was then filtered through a bed of celite and the filtrate was washed with ethyl acetate The filtrate was then concentrated at 350C (vac = 28 in Hg) using a rotary evaporator The residue was pu?fied using a silica gel column (4 1 heptane/ethyl acetate – ? 2 1 heptane/ethyl acetate) to give the desired product as a light yellow solid ( 17 10 g, 85 2 mmol, 93%) 1H NMR (400 MHz, CHLOROFORM-^) delta ppm 4 53 (s, 2H) 7 19 (d, I H) 7 29 (d, IH) 7 49 (s, IH)
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1,2-Dichloro-4-iodobenzene, and friends who are interested can also refer to it.
Reference:
Patent; DOV PHARMACEUTICAL, INC.; WO2008/57575; (2008); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com