Some common heterocyclic compound, 202982-68-1, name is 1-Chloro-4-fluoro-2-iodobenzene, molecular formula is C6H3ClFI, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 1-Chloro-4-fluoro-2-iodobenzene
To a suspension of 6-bromo- 1,2,3 ,4-tetrahydroisoquinolin- 1-one (1.0 g), 1-chloro-4-fluoro-2-iodobenzene (1.134 g), DMEDA (0.094 mL), and K3P04 (1.878 g) in toluene (10 mL) was added CuT (0.084 g) under nitrogen flow, and the mixture was stirred at 90C under nitrogen atmosphere overnight. Then, 1-chloro-4-fluoro-2-iodobenzene (0.3 g) was added thereto at room temperature, and the mixture was stirred at 90C under nitrogen atmosphere overnight. The mxiture was cooled, and then concentrated. The resulted crude product was purified by medium- pressure column chromatography (Hexane/AcOEt) to give 6-bromo-2-(2-chloro-S-fluorophenyl)- 1,2,3 ,4-tetrahydroisoquinolin- 1-one (0.75 g).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 202982-68-1, its application will become more common.
Reference:
Patent; OTSUKA PHARMACEUTICAL CO., LTD.; KAN, Keizo; TAKUWA, Masatoshi; TANAKA, Hirotaka; FUJIWARA, Hideto; YAMABE, Hokuto; MATSUDA, Satoshi; OHDACHI, Kazuhiro; HANARI, Taiki; MENJO, Yasuhiro; URUSHIMA, Tatsuya; FUJITA, Shigekazu; (183 pag.)WO2019/4421; (2019); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com