Adding a certain compound to certain chemical reactions, such as: 146137-72-6, name is 2-Fluoro-6-iodobenzaldehyde, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 146137-72-6, category: iodides-buliding-blocks
General procedure: Acetyl phenyl boronic acid derivatives (3.78 g, 20.77 mmol) were reacted with halogen containing aldehyde partners (4 g, 16 mmol) or alternatively, aldehyde phenyl boronic acid starting materials (3.9 g, 21.13 mmol) were reacted with halogen substituted acetophenones (4.0 g, 16.25 mmol) for the Suzuki coupling reaction. Thus, aryl halide and polymer bound Pd (PPh3)4 (0.25 g, 1.35 mol%) were added to a dioxane-ethanol (30 mL, 4:1) mixture. This was followed by the addition of triethylamine (1.17 mL, 32 mmol) and the boronic acid derivative. The resultant solution was degassed several times with argon and stirred in ice or refluxed for 6-48 h depending upon the starting materials used. After the reaction, the mixture was filtered through celite and evaporated to dryness. The crude material was purified by column chromatography (10-20% ethyl acetate/ hexane) to obtain pure intermediates 5a-5h.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Fluoro-6-iodobenzaldehyde, and friends who are interested can also refer to it.
Reference:
Article; Sharma, Horrick; Sanchez, Tino W.; Neamati, Nouri; Detorio, Mervi; Schinazi, Raymond F.; Cheng, Xiaolin; Buolamwini, John K.; Bioorganic and Medicinal Chemistry Letters; vol. 23; 22; (2013); p. 6146 – 6151;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com