Electric Literature of 98-61-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 98-61-3, name is 4-Iodobenzenesulfonyl chloride belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
General procedure: A aqueous solution (15mL) containing 4mmol of corresponding sulfonyl chloride, 4mmol of sodium sulfite, 4mmol of sodium hydrogenocarbonate and 2mmol corresponding 2-chloromethylated imidazo[1,2-a]pyridines was heated under microwave irradiation (120C, 5bars) in a sealed vial. After disappearance of the starting materials (about 1h), monitored by TLC, the solid was collected by filtration and dried under reduced pressure to give, after purification by column chromatography on silica gel and/or recrystallization, the expected product in 25-100% yield.
The synthetic route of 4-Iodobenzenesulfonyl chloride has been constantly updated, and we look forward to future research findings.
Reference:
Article; Castera-Ducros, Caroline; Paloque, Lucie; Verhaeghe, Pierre; Casanova, Magali; Cantelli, Christophe; Hutter, Sebastien; Tanguy, Floriane; Laget, Michele; Remusat, Vincent; Cohen, Anita; Crozet, Maxime D.; Rathelot, Pascal; Azas, Nadine; Vanelle, Patrice; Bioorganic and Medicinal Chemistry; vol. 21; 22; (2013); p. 7155 – 7164;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com