Some common heterocyclic compound, 103440-52-4, name is Methyl 2-Iodo-5-methylbenzoate, molecular formula is C9H9IO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 103440-52-4
STEP-7: To a stirred solution of compound-7 (1.0 eq) in 20 Vol of carbon tetrachloride and added N-bromosuccinimide (1.1 eq) followed by catalytic amount of benzoyl peroxide (0.1 eq). Reaction mixture was later refluxed for 24 h. The reaction mixture was filtered to remove succinmide and the filtrate was washed with brine, dried over anhydrous Na2SO4 and evaporated under reduced pressure. Crude residue was purified by silica gel chromatography Results: TABLE 7 1H NMR (CDCl3, 400 MHz) delta splitting pattern and J value Protons Group 7.63 d 1 H ArH 7.54 d 1 H ArH 7.04 d 1 H ArH 4.56 s 2 HCH2Br 3.88 s 3 HOCH3
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 103440-52-4, its application will become more common.
Reference:
Patent; KRISANI BIOSCIENCES (P) LTD; US2011/281893; (2011); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com