In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 54811-38-0 as follows. category: iodides-buliding-blocks
Under nitrogen protection,5-iodo-2-methylbenzoic acid (49.33 g, 0.188 mol) was added to anhydrous dichloromethane(300 mL), to which oxalyl chloride (26. 27 g, 0.207 mol) was added with stirring. N, N-dimethylformamide (1.64 g, 18. 8-01) was slowly added dropwise, and a large amount of gas was generated, and the dropping speed was slow.After the addition was complete, the mixture was stirred at room temperature overnight and the solution became clear. HPLC control reaction (take 0. lmL reaction solution dissolved in lmL methanol, shake at room temperature 5-lOmin, take a little by HPLC analysis.), The organic volatiles were evaporated in vacuo on a rotary evaporator to give 5-iodo-2-methylbenzoyl chloride
According to the analysis of related databases, 54811-38-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; SHANGHAI TIANCI BIOLOG VALLEY BIOLOG ENGINEERING CO LTD; Li, XinJuanZi; Wang, Xun; Ma, Xilai; Li, Yonggang; Lu, Xinghong; Li, Jianzhi; (21 pag.)CN103570671; (2016); B;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com