Reference of 1643-29-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1643-29-4 name is 3-(4-Iodophenyl)propanoic acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: 3-(4-Iodophenyl)propanoic acid (7)33 (1.0 equiv) was added to SOCl2 (0.2 mmol/mL) under a nitrogen atmosphere. The mixture was refluxed for 1.5 h after which the SOCl2 was evaporated in vacuo. The residue was co evaporated 2 times with toluene and subsequently dissolved in toluene (0.1 mmol/mL). Methyl-2-aminobenzoate or methyl 2-aminothiophene-3-carboxylate (1.4 equiv) was added and the mixture was stirred overnight at room temperature under a nitrogen atmosphere. Upon completion of the reaction, the precipitate was filtered off and the filtrate was concentrated. The obtained residue was purified by column chromatography (Pet. Et/EtOAc 4:1) to give the target compound.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-(4-Iodophenyl)propanoic acid, and friends who are interested can also refer to it.
Reference:
Article; Van Veldhoven, Jacobus P.D.; Liu, Rongfang; Thee, Stephanie A.; Wouters, Yessica; Verhoork, Sanne J.M.; Mooiman, Christiaan; Louvel, Julien; Ijzerman, Adriaan P.; Bioorganic and Medicinal Chemistry; vol. 23; 14; (2015); p. 4013 – 4025;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com