In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2265-91-0, name is 1,3-Difluoro-5-iodobenzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Safety of 1,3-Difluoro-5-iodobenzene
A solution of feri-butyl piperazine- l-carboxylate (2 g, 17.54 mmol), l,3-difluoro- 5-iodobenzene (4.2 g, 17.50 mmol), NaOtBu (2.5 g), BINAP (108 mg, 0.17 mmol), and Pd2(dba)3 (160 mg, 0.17 mmol) in toluene (20 mL) was stirred for 16 h at 80 C, then quenched by the addition of 40 mL FLO. The resulting solution was extracted with 2×40 mL of EtOAc, and the combined organic layers were concentrated under vacuum and purified with silica gel chromatography using EtOAc / hexane (1/2) to afford 3.1 g (59%) of the title compound as an off-white solid. LC-MS: (ES, m/z) 299 NMR (400 MHz, DMSO -d6) d 6.69 – 6.57 (m, 2H), 6.49 (tt, J = 9.3, 2.2 Hz, 1H), 3.42 (t, J = 5.3 Hz, 4H), 3.26 – 3.13 (m, 4H), 1.42 (s, 9H).
The synthetic route of 2265-91-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; CENTAURUS THERAPEUTICS; ROMERO, Donna, L.; BLITZER, Jeremy; (242 pag.)WO2019/140188; (2019); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com