Related Products of 6213-88-3, A common heterocyclic compound, 6213-88-3, name is (E)-Methyl 3-iodoacrylate, molecular formula is C4H5IO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Methyl (2E)-3-iodoprop-2-enoate (0.141 g, 0.665 mmol), Pd(OAc)2 (15 mg, 0.067 mmol), ligand (0.13 mmol) and AgOAc (0.120 g, 0.721 mmol) were added to dry flasks under argon in the absence of light. Degassed MeCN (4.0 mL) was added to each flask, followed by 4,4,6-trimethyl-2-vinyl-1,3,2-dioxaborinane (0.13 mL, 0.76 mmol) under a positive pressure of argon. The flasks were then purged with argon for 2 min, and then stirred vigorously at room temperature, with conversion monitored at 1.5 h, 3 h and 24 h by 1HNMR. The HM:SM ratio was also determined by 1H NMR spectroscopy.
The synthetic route of 6213-88-3 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Madden, Katrina S.; Knowles, Jonathan P.; Whiting, Andrew; Tetrahedron; vol. 75; 45; (2019);,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com