Electric Literature of 33184-48-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 33184-48-4, name is 4-Chloro-2-iodo-1-methylbenzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Step 1: 5-Chloro-2-methylbenzaldehyde To a solution of 4-chloro-2-iodo-1-methylbenzene (5.0 g, 19.8 mmol) in THE (40 mL) n-BuL (2.5 M fl hexane, 8.72 mL, 21.8 mmoA) was sAowVy added dropwse at -78 C under argon. The mixture was stirred at -78 C for 1 h, then DME (7.7 mL, 99 mmol) was added, foWowed by warming to room temperature n 4 h and quenching wfth 1 N HC (5 mL). The reacton mixture was stirred overnight, dUuted wfth iN HC (50 mL) and Et20, the organc phase wasseparated, washed wfth aqueous brine, dried over Na2SO4 and evaporated to give the tte compound (314 g, 94%) as a yeWow oN,1H NMR (600 MHz, DMSO-d6) 10.17 (s, 1H), 7.80 (d, J = 2.2 Hz, 1H), 7.60 (dd, J = 2.4, 8.1 Hz, 1H), 7.37 (d, J8.1 Hz, 1H), 2.57 (s, 3H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Chloro-2-iodo-1-methylbenzene, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; NERVIANO MEDICAL SCIENCES S.R.L.; BRASCA, Maria Gabriella; BINDI, Simona; CALDARELLI, Marina; NESI, Marcella; ORRENIUS, Sten Christian; PANZERI, Achille; WO2014/19908; (2014); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com