Electric Literature of 103962-05-6,Some common heterocyclic compound, 103962-05-6, name is 1-Iodo-4-(trifluoromethoxy)benzene, molecular formula is C7H4F3IO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of 5-Bromo-4,6-dimethyl-pyridin-2-amine (2 g), Cesium carbonate (6.46 g), 4- Trifluoromethoxy iodobenzene (4.29 g), Palladium (II) acetate (0.22 g, 0.99 minol) and 4,5- Bis(diphenylphosphino)-9,9-dimethylxanthene (0.57 g) was taken up in Toleune (40 mL) and degassed with nitrogen gas and heated at 120 °C for 5 h. The reaction was diluted with Water (50 mL) and extracted with Ethyl acetate (2 X 30 mL) and the combined organic extracts were driedover anhydrous Sodium sulphate and evaporated under reduced pressure. The residue was subjected to Silica gel flash column chromatography eluting with a gradient of Ethyl acetate and Heptane to obtain the title compound as an off white solid (2.7 g, 75 percent). LCMS: Rt: 2.44 min; MS:mz = 363.2 (M+2) 1H NMR (300 MHz, CDCI3) 6 7.36 (d, J = 9.0 Hz, 2H), 7.24 (d, J = 8.8 Hz, 2H), 2.66 (5, 3H), 2.39 (5, 3H).
The synthetic route of 103962-05-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BASF SE; SAMBASIVAN, Sunderraman; NARINE, Arun; CHAUDHURI, Rupsha; VALLINAYAGAM, Ramakrishnan; VYAS, Devendra; ADISECHAN, Ashokkumar; DATTA, Gopal Krishna; (196 pag.)WO2018/108671; (2018); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com