17024-12-3, name is 9-Iodophenanthrene, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 17024-12-3
Synthesis of 1-[5-(1 ,1 ,3,3-tetramethylisoindolin-2-yloxylyl)-2-[9-(phenanthryl)]acetylene; 205 2079-lodophenanthrene (59 mg, 0.194 mmol), DABCO (62.5 mg, 0.557 mmol, 3 equiv) and Pd(OAc)2 (1 mg, 2.5 mol %) was dissolved in dry MeCN (1 cm3). 5-ethynyl- 1,1,3,3-tetramethylisoindolin-2-yloxyl 205 (50 mg, 0.233 mmol, 1.2 equiv) was added and mixture heated at 80 0C under argon for 4 h. Subsequently the solvent was removed under reduced pressure and the residue taken up in CHCI3 (~1 ml) ensuring the DABCO remained undissolved. Purification of the resulting solution by column chromatography (SiO2, eluant:10 % EtOAc, 90 % n-Hexane) gave 1 -[5-(1 , 1,3,3- tetramethylisoindolin-2-yloxylyl)-2-[9-(phenanthryl)]acetylene, 207 (68 mg, 0.175 mmol, 90 %).
The synthetic route of 17024-12-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; QUEENSLAND UNIVERSITY OF TECHNOLOGY; WO2007/124543; (2007); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com