Synthetic Route of 5100-98-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5100-98-1, name is 3-Chloro-2-iodotoluene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
(a) 1-(bromomethyl)-3-chloro-2-iodobenzene. To a solution of 1-chloro-2-iodo-3-methylbenzene (4.0 g, 16 mmol) in CCl4 (12 mL), wereadded N-bromosuccinimide (5.6 g, 32 mmol) and 1,1′-azobis(cyclohexanecarbonitrile) (3.9 g, 16 mmol).The mixture was degassed with nitrogen and then heated at 90 °C for 1h. After cooling to roomtemperature, silica gel was added, and the solvent was removed in vacuo. Purification by flash columnchromatography (SiO2; 0 – 5percent EtOAc /hexanes) provided the title compound as an oil (3.7 g, 70percent yield).1H NMR (400 MHz, CDCl3): delta 7.37 (m, 2H), 7.29 ? 7.23 (m, 1H), 4.65 (s, 2H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Chloro-2-iodotoluene, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Maher, Michael P.; Wu, Nyantsz; Ravula, Suchitra; Ameriks, Michael K.; Savall, Brad M.; Liu, Changlu; Lord, Brian; Wyatt, Ryan M.; Matta, Jose A.; Dugovic, Christine; Yun, Sujin; Ver Donck, Luc; Steckler, Thomas; Wickenden, Alan D.; Carruthers, Nicholas I.; Lovenberg, Timothy W.; Journal of Pharmacology and Experimental Therapeutics; vol. 357; 2; (2016); p. 394 – 414;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com