Reference of 54811-38-0, These common heterocyclic compound, 54811-38-0, name is 5-Iodo-2-methylbenzoic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 553-[4-Methyl-3-[[(tricycIo[3.3.1.13)7]dec-l-ylmethyl)amino]carbonyl]phenyl]-2-pyridinecarboxylic acida) 5-Iodo-2-methyl-7V-(tricyclo[3.3.1.13>7]dec-l-ylmethyl)-benzamide5-Iodo-2-methyl-benzoic acid (3.0 g) was stirred in dichloromethane (40 mL) undernitrogen. Oxalyl chloride (5 mL) was added followed by JV.JV-dimethylfonnamide (1 drop).After 2 hours the volatiles were removed under vacuum and the residue was redissolved indichloromethane (40 mL). Tricyclo[3.3.1.13>7]decane-l-methanamine (2.23 mL) andtriethylamine (3.18 mL) were added and the mixture was stirred under nitrogen for 2 hours.2M aqueous hydrochloric acid was added, the layers were separated and the aqueousfraction was extracted twice with dichloromethane. The combined organics were washedwith water, brine, dried (MgSO/O, filtered and concentrated in vacua. Purification bytrituration with diethyl ether afforded the sub-title compound (4.7 g).MS: APCI(+ve) 410 (M+H4).
The synthetic route of 54811-38-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ASTRAZENECA AB; WO2006/25783; (2006); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com