Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6828-35-9, name is 5-Chloro-2-iodoaniline, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 5-Chloro-2-iodoaniline
Under nitrogen protection, 4-((1S,4S)-4-(but-3-yn-2-yl)cyclohexyl)-6-fluoroquinoline (110 mg,0.39 mmol), 5-chloro-2-iodoaniline (99 mg, 0.39 mmol) and Et3N (118 mg, 1.2 mmol) of N,N-dimethylacetamideCuI (8 mg, 0.04 mmol) and Pd(PPh3)2Cl2 (29 mg, 0.04 mmol) were sequentially added to the solution (3 mL), and the reaction mixture was added.The reaction was stirred at room temperature for 4 h. TLC showed that after the reaction of the starting material was completed, NaOH (160 mg, 4.0 mmol) was added, and the temperature was raised to 140.Stir at C overnight, cool to room temperature, add water to the reaction mixture to quench, extract three times with EA, and combine with organicWash with brine, dry with anhydrous Na2SO4,The crude product obtained by concentration is passed through a thin layer chromatography plate.(DCM / MeOH = 25 / 1) was isolated and purified to give the title compound (90 mg, yield: 77%) as pale yellow solid.
According to the analysis of related databases, 6828-35-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Chengdu Hai Borui Pharmaceutical Co., Ltd.; Chengdu Beite Pharmaceutical Co., Ltd.; Huang Haoxi; Liu Guanfeng; Ren Junfeng; Yi Shoubing; Chen Tonghun; He Quanhong; Wu Xiancai; Li Yingfu; Su Zhonghai; (97 pag.)CN109574988; (2019); A;,
Iodide – Wikipedia,
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