Related Products of 444-29-1, A common heterocyclic compound, 444-29-1, name is 1-Iodo-2-(trifluoromethyl)benzene, molecular formula is C7H4F3I, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A mixture of aryl halide (1.0 mmol), DAAD (1.1 mmol), and CuI (9 mg, 0.05 mmol) in DMF (2 mL) was stirred for 30 min at 0 °C. A suspension of NaH (0.050 g, 1.1 mmol) in DMF (1 mL) was slowly added to the reaction mixture over 20 min. The mixture was then evacuated and back-filled with N2 (3 times) and stirred for 12?20 h at the appropriate temperature. The crude reaction mixture was diluted with CH2Cl2 (5 mL) and a saturated NH4Cl solution (3 mL). The mixture was stirred for an additional 30 min and two layers were separated. The aqueous layer was extracted with CH2Cl2 (3 2 mL). The combined organic layers were dried over MgSO4, filtered, and concentrated in vacuo. The residue was purified by flash column chromatography (silica gel, hexane/EtOAc 3:1) to give the desired product.
The synthetic route of 444-29-1 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Samzadeh-Kermani, Alireza; Tetrahedron Letters; vol. 57; 4; (2016); p. 463 – 465;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com