Application of 156150-67-3, The chemical industry reduces the impact on the environment during synthesis 156150-67-3, name is 2-Chloro-1-fluoro-4-iodobenzene, I believe this compound will play a more active role in future production and life.
2-chloro-1-fluoro-4-iodobenzene (771) mg) In the dioxane (5 mL) solution of tert-butyl 5-hydroxy-4-methyl-2,3-dihydro-1H-indole- 1-carboxylate (500 mg), and copper iodide (I) (38.2 mg), N,N-dimethylglycine (41.4 mg) and cesium carbonate (1.31 g) were added, and it stirred at 100 degrees C for 3 hours and 25 minutes. Cerite filtration of the reaction mixture was carried out after cooling to a room temperature. The mark compound (57.8 mg) was obtained as a colorless solid by condensing under decompression of the obtained filtrate and refining residue with silica gel column chromatography (ethyl acetate/hexane).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Chloro-1-fluoro-4-iodobenzene, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; DAIICHI SANKYO COMPANY LIMITED; NAGAMOCHI, MASATOSHI; GOTANDA, KENTOKU; GOTO, TAIJI; SASAKI, JUNKO; YOSHINO, TOSHIHARU; ISOBE, TAKASHI; (75 pag.)JP2016/128387; (2016); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com