Application of 1829-28-3, The chemical industry reduces the impact on the environment during synthesis 1829-28-3, name is Ethyl 2-iodobenzoate, I believe this compound will play a more active role in future production and life.
In a test tube equipped with a stirrer and a septum cap, trifluoromethylzinc iodide (DMPU) 2 complex (160 mg, 0.2 mmol) prepared in Example 1 and copper (I) iodide (1.9 mg, 0.01 mmol ) Was charged, and argon substitution was carried out three times. Then, a solution of ethyl 2-iodobenzoate (16.6 mul, 0.1 mmol) in DMPU (0.2 ml) was added, the septum cap was replaced with a screw chap, and the reaction was carried out at 50 ° C. for 24 hours. After completion of the reaction, the reaction solution was quantified with 19 F-NMR (benzotrifluoride internal standard), and ethyl 2-trifluoromethylbenzoate was produced with a yield of 80percent
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 2-iodobenzoate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; TOKYO INSTITUTE OF TECHNOLOGY; TOSOH F-TECH INCORPORATED; MIKAMI, MIKAMI; NAKAMURA, YUZO; NEGISHI, KAZUYUKI; AIKAWA, KOHSUKE; (8 pag.)JP5889817; (2016); B2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com