Electric Literature of 460-37-7, A common heterocyclic compound, 460-37-7, name is 1,1,1-Trifluoro-3-iodopropane, molecular formula is C3H4F3I, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Compound 2 was added to 21 three-necked bottles(5 (^, 0.167111 O1), 0.5111 O1 / 1He 0 field of liquid(84011 ^), stirmixLOmin. A solution of trifluoroiodopropaneLt; / RTI & gt;The reaction was stirred at room temperature4-5 hours.Add 5001 ^AcetateThe organic phase was dried over anhydrous sodium sulfate, filtered and the filtrate was evaporated to dryness to give 55.5 g of a yellow solid in 84% yield.
The synthetic route of 460-37-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Zhejiang Yongning Pharmaceutical Co., Ltd; YE, TIANJIAN; LU, XIUWEI; YU, GUAMGLIANG; HE, SI; PAN, PENG; TIAN, JIAHUA; (10 pag.)CN105949258; (2016); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com