Electric Literature of 627-32-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 627-32-7, name is 3-Iodo-1-propanol belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Example 191 Preparation of 4-[6,6-dimethyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]-1-(3-hydroxyropyl)pyridinium iodideA mixture of Example 1 (57 mg, 172 muetaetaomicronIota), 3-iodopropan-1 -ol (2eq), K2CO3 (4eq) in DMF (1 mL) was stirred at RT for 16 h and then at 100C for 16h. Filtered, concentrated and purified by preparative HPLC (Column: XBridge C18 5muetaiota 100×30 mm; Solvent A: Water + 0.1 % TFA; Solvent B: Acetonitrile; Gradient; 0-8 min, 20-40% B: Flow: 70 mL/min) to give the desired product (25 mg, 30%).1 H-NMR (400 MHz ,DMSO-d6), d [ppm]= 1 .09 (6H), 1 .97 (2H), 2.29-2.39 (3H), 2.82 (2H), 3.39 (2H), 4.38 (2H), 6.71 (2H), 6.78 (1 H), 7.09-7.17 (2H), 7.73 (2H), 8.12 (1 H), 8.66 (2H), 12.38 (1 H).
The synthetic route of 3-Iodo-1-propanol has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; GRAHAM, Keith; KLAR, Ulrich; BRIEM, Hans; HITCHCOCK, Marion; BAeRFACKER, Lars; EIS, Knut; SCHULZE, Volker; SIEMEISTER, Gerhard; BONE, Wilhelm; SCHROeDER, Jens; HOLTON, Simon; LIENAU, Philip; TEMPEL, Rene; SONNENSCHEIN, Helmut; BALINT, Jozsef; GRAUBAUM, Heinz; (577 pag.)WO2015/193339; (2015); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com