Reference of 755027-18-0, These common heterocyclic compound, 755027-18-0, name is 1-Bromo-4-iodo-2-methoxybenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of pyrazole-4-amine dihydrochloride (0.75 g, 4.79 mmol), salicylaldoxime (0.13115 g, 0.96 mmol), cesium carbonate (4.69 g, 14.38 mmol), cuprous oxide (0.06 g, 0.29 mmol), 1-bromo-4-iodo-2-methoxybenzene (1.5 g, 4.79 mmol) and N, N-dimethyl-formamide (5 ml) werecombined in a microwave vial fitted with an N2 inlet and magnetic stir bar. The reaction mixture wasstirred under a nitrogen atmosphere at 90 oc overnight. The solution obtained was allowed to coolto RT, then filtered through celite and the filtrate was concentrated in vacuo. The crude material20 was purified by silica gel chromatography (10% to 60% EtOAc in heptanes) to give 1-(4-bromo-3-methoxyphenyl)-1 H-pyrazol-4-amine (250 mg, MS: 270.2 [M+H+].)
Statistics shows that 1-Bromo-4-iodo-2-methoxybenzene is playing an increasingly important role. we look forward to future research findings about 755027-18-0.
Reference:
Patent; NOVARTIS AG; CHEUNG, Atwood; CHIN, Donovan Noel; DALES, Natalie; FAZAL, Aleem; HURLEY, Timothy Brian; KERRIGAN, John; O’BRIEN, Gary; SHU, Lei; SUN, Robert; SUNG, Moo; WO2014/28459; (2014); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com