Related Products of 886762-71-6,Some common heterocyclic compound, 886762-71-6, name is 1-Fluoro-3-iodo-2-nitrobenzene, molecular formula is C6H3FINO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
NaHCOs [5.70 g, 67.8 mmol] was added to a stirred solution of compound 3 [5.00 g, 22.6 mmol] in water (30 mL) at room temperature under argon atmosphere and stirred for 10 minutes. Finally, solution of compound 2 [4.22 g, 15.8 mmol] in EtOH (40 mL) was added to the reaction mixture and stirred at 80 C for 4 h. After completion, solvent was evaporated, crude was diluted with water [200 mL] and extracted with Et?.0 [200 mLj. Organic part was separated; pH of the aqueous part was slowly adjusted to 2-3 using 1 (N) aqueous HC1 under ice cooled condition and immediately extracted with EtOAc [2×100 mi]. Organic part was separated, dried [Na2SQ4] and concentrated under reduced pressure to afford compound 4 [4.5 g, 43%]. Mass [ESI]: m/z 468.27 [M++l ]
The synthetic route of 886762-71-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; CYTOSITE BIOPHARMA INC.; BILCER, Geoffrey, Malcolm; KELLY, Terence, Alfred; (190 pag.)WO2019/160916; (2019); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com