Adding a certain compound to certain chemical reactions, such as: 619-58-9, name is 4-Iodobenzoic acid, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 619-58-9, Recommanded Product: 619-58-9
To a solution of 4-iodobenzoic acid (2.48 g, 10 mmol) in THF (40 mL) under argon were successively added freshly distilled Et3N (20 mL), PdCl2(PPh3)2 (421 mg, 0.6 mmol, 6 mol%), CuI (191 mg, 1.0 mmol, 10 mol%) and trimethylsilylacetylene (2.40 mL, 17 mmol). The mixture was stirred overnight at room temperature, then filtered through a pad of celite. The residue was washed with EtOAc (100 mL) and the organic phase was successively washed with aqueous 1M HCl solution (3 x 30 mL), water (50 mL) and brine (2 x 30 mL). After drying (MgSO4), filtration and concentration under reduced pressure, the crude residue was dissolved in dry CH2Cl2 (20 mL), and chloroacetonitrile (1 mL, 15 mmol) then Et3N (2.70 mL, 20 mmol) were added. The mixture was stirred at room temperature for 2 days, then the solvents were evaporated under reduced pressure. The residue was dissolved in EtOAc (10 mL) and water (20 mL) was added. The layers were separated and the aqueous phase was extracted with EtOAc (2 x 10 mL). The combined organic layers were successively washed with a saturated aqueous NaHCO3 solution and brine, dried over anhydrous MgSO4, filtrered and concentrated under reduced pressure. The crude residue was purified by flash chromatography on silica gel (10% ethyl acetate/cyclohexane) to provide the pure acylcyanohydrin 8m (1.93 g, 75%) as a orange solid.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Iodobenzoic acid, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Pantin, Mathilde; Bodinier, Florent; Saillour, Jordan; Youssouf, Yassine M.; Boeda, Fabien; Pearson-Long, Morwenna S.M.; Bertus, Philippe; Tetrahedron; vol. 75; 33; (2019); p. 4657 – 4662;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com