Related Products of 351003-36-6,Some common heterocyclic compound, 351003-36-6, name is 2-Fluoro-5-iodobenzonitrile, molecular formula is C7H3FIN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
2-Fluoro-5-iodobenzonitrile (2.0 g, 7.3 mmol) was dissolved in THF (13 mL) and cooled to -35 C., then i-PrMgCl (sol. in THF, 1.5M, 7.3 mL) was slowly added while maintaining the temperature. The mixture was stirred at -25 C. for 1 h and then transferred to a cooled (-70 C.) THF (9 mL) solution of 4-bromobenzoyl chloride (3.20 g, 14.6 mmol). After 1 h stirring at -70 C. the mixture was allowed to slowly attain rt. Concentration and addition of water (100 mL) gave a slurry that was neutralised. Extractive workup (EtOAc, NaHCO3 (aq, sat), brine), drying (Na2SO4) of the combined extracts and concentration furnished, after purification by chromatography, 5-(4-bromobenzoyl)-2-fluorobenzonitrile (1.53 g, 69%).
The synthetic route of 351003-36-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BIS-AROMATIC COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATION; US2010/286215; (2010); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com