The synthetic route of 19094-56-5 has been constantly updated, and we look forward to future research findings.
19094-56-5, name is 2-Chloro-5-iodobenzoic acid, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. name: 2-Chloro-5-iodobenzoic acid
Example 3; 4′-Chloro-3′-[[(cyclohexylmethyl)amino]carbonyl]-[l,l’-biphenyl]-2-carboxylic acid; EPO a) 2-Chloro-5-iodo-benzoic acid, 1,1-dimethylethyl ester; iV,iV-Dimethylformamide (1 drop) and oxalyl chloride (4.8 mL) were added to a stirred solution of 2-chloro-5-iodobenzoic acid (5 g) in dichloromethane (20 mL) at 0 C. The reaction was allowed to warm to room temperature, stirred under nitrogen for 2 hours, and then evaporated to dryness. The residue was dissolved in tetrahydrofuran (20 mL) and cooled to 0 0C. Potassium terf-butoxide (22 mL, 1 M solution in tetrahydrofuran) was added over 10 minutes. The reaction was allowed to warm to room temperature and stirred under nitrogen for 2 hours then poured into saturated aqueous sodium bicarbonate (50 mL). The layers were separated and the aqueous was extracted with diethyl ether (50 mL). The combined organics were dried, filtered and evaporated to afford the sub-title compound as an oil (5.7 g).1HNMR (400 MHz, d6-DMSO) delta 7.99 (IH, d), 7.87 (IH5 dd), 7.34 (IH, d), 1.54 (9H, s).
The synthetic route of 19094-56-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ASTRAZENECA AB; WO2006/80884; (2006); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com