Adding a certain compound to certain chemical reactions, such as: 188815-32-9, name is 3-Bromo-5-iodobenzoic acid, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 188815-32-9, Safety of 3-Bromo-5-iodobenzoic acid
To a solution of 3-bromo-5-iodobenzoic acid (53, 500 mg, 1.53 mmol) in methanol (7.5 mL) was added dropwise thionyl chloride (1.1 mL, 2.18 g, 18.35 mmol) at 0 C, and then this reaction mixture was stirred at room temperature for 15 h. After being neutralized with saturated NaHCCb solution on the ice bath, the mixture was extracted with ethyl acetate (20 mL x2). The combined organic layer was washed with brine, dried over MgS04, filtered and evaporated under reduced pressure to afford compound 54 (498 mg, 96%) as a white solid; NMR (400 MHz, CDCb) d 8.32 (t, J =1.40 Hz, 1H), 8.15 (t, J =1.58 Hz, 1H), 8.06 (t, J =1.64 Hz, 1H), 3.95 (s, 3H); MS (ESI, m/z) 340.9, 342.9 [M+l]+; ESI-HRMS calcd. m/z for C8H702I79Br 340.8674, found 340.8672 [M+l]+.
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Reference:
Patent; THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES; JACOBSON, Kenneth A.; YU, Jinha; CIANCETTA, Antonella; WEN, Zhiwei; JUNG, Young-Hwan; (124 pag.)WO2019/157417; (2019); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com