Some common heterocyclic compound, 51628-12-7, name is 2-(4-Iodophenyl)acetonitrile, molecular formula is C8H6IN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C8H6IN
iodophenyl cyanide(10 mmol, 2.28 g), Na2C03 (0.5 mmol, 57 mg)Soluble in tetrahydrofuran / water(Nu: nu = 3: 1) in a mixed solvent,After the reaction was stopped for 6 hours, the reaction was stopped. After allowing to stand at room temperature, the solvent was dried and usedSilica gel column chromatography to obtain a white solid after purification of p-iodobenzamide 2. 2 g (Yield: 89%);
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 51628-12-7, its application will become more common.
Reference:
Patent; Suzhou University of Science and Technology; ZHOU, YUYANG; WANG, XIAOMEI; YE, CHANGQING; ZHU, SAIJIANG; XU, PENGJIE; LIANG, ZUOQIN; (6 pag.)CN104016913; (2016); B;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com