Related Products of 103962-05-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 103962-05-6, name is 1-Iodo-4-(trifluoromethoxy)benzene, This compound has unique chemical properties. The synthetic route is as follows.
A mixture of compound 03-1-3 (2.50 g, 7.52 mmol, 1.0 eq), 1-iodo-4- (trifluoromethoxy)benzene (3.25 g, 11.3 mmol, 1.5 eq), CuI (143.2 mg, 752.1 mumol, 0.1 eq), (1S,2S)-N1,N2-dimethylcyclohexane-1,2-diamine (321.0 mg, 2.26 mmol, 0.3 eq) and K3PO4 (3.19 g, 15.0 mmol, 2.0 eq) in toluene (3.0 mL) was heated at 110 °C for 12 h under N2. The reaction mixture was diluted with H2O (100 mL) and extracted with ethyl acetate (80 mL*4). The combined organic layers were washed with brine (20 mL*3), dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure to give a residue. The residue was purified by column chromatography (SiO2) to give compound 03-1-4 (3.00 g, 74percent). M+H+ = 393.2 (LCMS).
The chemical industry reduces the impact on the environment during synthesis 1-Iodo-4-(trifluoromethoxy)benzene. I believe this compound will play a more active role in future production and life.
Reference:
Patent; KYRAS THERAPEUTICS, INC.; VACCA, Joseph P.; LI, Dansu; (587 pag.)WO2017/96045; (2017); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com