Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 260355-20-2, name is 1-Chloro-4-iodo-2-(trifluoromethyl)benzene, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C7H3ClF3I
Ethyl 1 H-pyrazole-4-carboxylate (20 g), 1-chloro-4-iodo-2 – (trifluoromethyl) benzene (44 g)Copper iodide (2.7 g),(1 S, 2 S) -N 1, N 2 -dimethylcyclohexane-1, 2-diamine (3.0 g)Sodium ascorbate (2.8 g), sodium carbonate (30 g)In dimethylsulfoxide (80 mL) was stirred at 150 C. for 6 hours.After cooling at room temperature, the reaction solution was added to toluene (0.45 liter), And 10% saline (0.50 l) was added thereto, followed by stirring at room temperature for 30 minutes.After insoluble matter was filtered off with Celite (registered trademark), the two layers were separated.The aqueous layer was extracted with toluene (0.20 l), and the combined organic layer was washed with 10% brine (0.30 l) and then dried over anhydrous magnesium sulfate.The solvent was distilled off under reduced pressure, and the obtained residue was purified by OH type silica gel column chromatography (hexane: ethyl acetate = 90: 10 ? 25: 75) to give the title compound (23 g) as a pale red solid It was
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 260355-20-2.
Reference:
Patent; TAISHO PHARMACEUTICAL COMPANY LIMITED; KAWABE, KENICHI; YAMAMOTO, KUMIKO; UNEUCHI, FUMITO; ASANUMA, YUTA; YAMAGUCHI, CHITOSE; USHIKI, YASUNOBU; SHIBATA, TSUYOSHI; OHTA, HIROSHI; (254 pag.)JP2018/83767; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com