Related Products of 58755-70-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 58755-70-7 as follows.
Intermediate 5: (“2£r)-3-(4-Methoxgamma-2-nitrophenyl’)acrylate A solution of 4-iodo-3-nitroanisole (10 g, 36 mmol), methylacrylate (3.87 mL, 43 mmol), tris(4-methylphenyl)phosphine (1.1 g, 3.6 mmol) and triethylamine (6.05 mL, 43 mmol) was degassed and flushed with nitrogen. Palladium(II) acetate (1.2 g, 1.8 mmol) was added and the mixture was heated at 7O0C overnight. It was filtered through a 0.45 mum membrane and the solvent was removed under reduced pressure. The residue was taken up in ethyl acetate (300 mL), it was washed with potassium phosphate buffer (IM, pH 7, 2x 300 mL) and dried over sodium sulfate. Chromatography on silica gel with dichloromethane, followed by precipitation from dichloromethane (50 mL) with hexanes (500 mL) gave 4.96 g (58% yield) of product as a yellow solid.MS (ES): 260.20 (MNa+) for CnHnNO51H-NMR (DMSO-cUi delta: 3.73 (s, 3H); 3.88 (s, 3H); 6.59 (d, IH); 7.33 (dd, IH); 7.57 (d, IH); 7.78 (d, IH); 7.94 (d, IH).
According to the analysis of related databases, 58755-70-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2006/134378; (2006); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com