Adding a certain compound to certain chemical reactions, such as: 204257-72-7, name is Methyl 2-fluoro-4-iodobenzoate, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 204257-72-7, Recommanded Product: Methyl 2-fluoro-4-iodobenzoate
b. Methyl 2-fluoro-4-iodo-5-nitrobenzoate (3). A modified procedure of Kakuta and coworkers was followed.2 To a solution of methyl 2-fluoro-4-iodobenzoate (2) (1.4 g, 5.0 mmol) dissolved in concentrated sulfuric acid (5 mL) was added a solution of concentrated nitric acid (6.0 mL) and concentrated sulfuric acid (9.0 mL) dropwise at 0 C with stirring. The reaction solution was then stirred at room temperature for 5 h. The reaction solution was poured onto ice (100 mE) and extracted with ethyl acetate. The combined organic layers were washed with saturated NaHCO3 (100 mE) and brine (50 mE) and then dried over sodium sulfate, filtered and concentrated in vacuo. The crude product was purified by column chromatography (150 mL Si02, 2% ethyl acetate:hexanes to 10% ethyl acetate:hexanes) to give 3 (1.27 g, 78%) as a green crystalline solid, m.p. 84-87 C: ?HNMR (400 MHz, CDC13) oe 8.50 (d, Jz 6.4, 1H), 7.87 (d, J= 9.6, 111), 3.97 (s, 3H); ?3C NMR (100.6MHz, CDC13)6 163.1, 162.3, 162.2, 160.4, 148.7, 131.1, 130.8, 129.1, 129.0, 119.4, 119.2, 92.7,92.6, 53.1 ; JR (neat) n 2987, 1703, 1602, 1560, 1532, 1440 cm?; LC-FAB-MS (M)+ calcd forC8H5FINO4 324.9247, found 324.9249.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-fluoro-4-iodobenzoate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY; WAGNER, Carl; MARSHALL, Pamela; JURUTKA, Peter; WO2015/130973; (2015); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com