Electric Literature of 461-17-6,Some common heterocyclic compound, 461-17-6, name is 1,1,1-Trifluoro-4-iodobutane, molecular formula is C4H6F3I, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Reference Example 69 fluoro-4-(4,4,4-trifluorobutoxy)benzoic acid By operating in the same manner as in Reference Example 68 and using 1,1,1-trifluoro-4-iodobutane, the title compound was obtained as colorless powder.1H-NMR (DMSO-d6) delta: 1.97 (2H, m), 2. 44 (2H, m), 4.13 (2H, t, J=6.3Hz), 6.89 (1H, t, J=2.0Hz), 6.90 (1H, m) 7.84 (1H, t, J=9.0Hz), 14.44 (1H, s).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,1,1-Trifluoro-4-iodobutane, its application will become more common.
Reference:
Patent; Takeda Chemical Industries, Ltd.; EP1447402; (2004); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com