Application of 202865-85-8, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 202865-85-8, name is 1-Bromo-4-iodo-2-methylbenzene, This compound has unique chemical properties. The synthetic route is as follows.
1-bromo-4-iodo-2-methylbenzene (12.5 g) and tert-butyl 5-hydroxy-4-methyl-2,3-dihydro-1H-indole-1-carboxylate (7.00 g) in dioxane (250 mL) solution, copper iodide (I) (107mg), N,N-dimethylglycine (116 mg) and cesium carbonate (18.3 g) was added, stirred for 5 hours and 30 minutes at 100C. Allowed to stand overnight, After cooling to room temperature, and stirred for 9 hours at again 100C, the reaction solution was filtered through Celite. The obtained filtrate was concentrated under reduced pressure, the residue was purified by silica gel column chromatography (dichloromethane/hexane) to give the title compound (5.26 g) as a colorless solid.
The chemical industry reduces the impact on the environment during synthesis 1-Bromo-4-iodo-2-methylbenzene. I believe this compound will play a more active role in future production and life.
Reference:
Patent; DAIICHI SANKYO COMPANY LIMITED; NAGAMOCHI, MASATOSHI; GOTANDA, KENTOKU; NOGUCHI, TETSUJI; GOTO, TAIJI; SASAKI, JUNKO; TORIHATA, MUNEFUMI; YOSHINO, TOSHIHARU; ISOBE, TAKASHI; (97 pag.)JP2016/108257; (2016); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com