Adding a certain compound to certain chemical reactions, such as: 35453-19-1, name is 5-Amino-2,4,6-triiodoisophthalic acid, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 35453-19-1, Computed Properties of C8H4I3NO4
A. Preparation of 5-Amino-2,4,6-triiodoisophthaloyl Chloride STR25 A slurry of 195.2 g. (0.35 mole) of 5-amino2,4,6-triiodoisophthalic acid in 300 ml. of thionyl chloride was refluxed for 24 hours. During the reflux period the solids dissolved. The solution was cooled to 40 and the solvent evaporated to dryness in vacuum. The gummy residue was dissolved in 250 ml. of tetrahydrofuran and evaporated to dryness. The residue was dissolved in 500 ml. of tetrahydrofuran and washed with a mixture of saturated sodium chloride solution and saturated sodium carbonate. The tetrahydrofuran solution was washed twice with saturated sodium chloride solution and dried over anhydrous calcium chloride. The solution was filtered, diluted with 500 ml. of benzene and evaporated to 450 ml. To this solution 450 ml. of petroleum ether (30-60) was added dropwise with stirring. After standing for 2 hours the solids were isolated and dried to yield 100.5 g. (48%). The material was pure as shown by tlc (silica plate-benzene/acetone 80/20).
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Reference:
Patent; Mallinckrodt, Inc.; US4307072; (1981); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com