Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 135050-44-1, name is 3-Chloro-4-iodoaniline, A new synthetic method of this compound is introduced below., name: 3-Chloro-4-iodoaniline
3-chloro-4-iodoaniline (15 g, 59 mmol) was dissolvedEthyl [(ethyloxy)methylene]malonate (19 mL, 95 mmol)It was heated at 160 C for 4 hours under a reflux condenser.The condenser was then removed and EtOH evaporated. After one hour,Cool it to rt and cure.Break up and suspend the solid in hexane.The mixture was filtered and the cake was washed several times with hexane.A grey solid (23 g, 91%) was obtained.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; BURY, MICHAEL JONATHAN; CASILLAS, LINDA N.; CHARNLEY, ADAM KENNETH; HAILE, PAMELA A.; MARQUIS, JR., ROBERT W.; MEHLMANN, JOHN F.; ROMANO, JOSEPH J.; SINGHAUS, JR., ROBERT R.; WANG, GREN Z.; (142 pag.)TW2018/8946; (2018); A;,
Iodide – Wikipedia,
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