3032-81-3, name is 1,3-Dichloro-5-iodobenzene, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 1,3-Dichloro-5-iodobenzene
General procedure: A suspension of coupling substrate 2d?g (1 equiv), copper(I) iodide (0.5 equiv), cesium carbonate (2 equiv), and the corresponding aryl halide (1 equiv) in dioxane was placed under a nitrogen atmosphere. The coupling ligand DMEDA (1 equiv) was added dropwise by using a syringe and the mixture was then stirred at r.t. for various periods of time (2.5?48 h). At the end of the reaction, all insoluble salts deposited after cooling at r.t. were collected by filtration then washed with dichloromethane. The resulting filtrate was concentrated in vacuo and the residue was partitioned between water and dichloromethane. The organic layer was dried over MgSO4 and evaporated to dryness. The reaction residues were recrystallized or purified by chromatography on silica gel column to afford pure compounds 36?39.
The synthetic route of 3032-81-3 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Baudelet, Davy; Daich, Adam; Rigo, Benoit; Lipka, Emmanuelle; Gautret, Philippe; Homerin, Germain; Claverie, Christelle; Rousseau, Jolanta; Abuhaie, Cristina-Maria; Ghinet, Alina; Synthesis; vol. 48; 14; (2016); p. 2226 – 2244;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com