Synthetic Route of 624-76-0, These common heterocyclic compound, 624-76-0, name is 2-Iodoethanol, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Compound 4a (617mg, 4.6mmol) was reacted with 2-Iodoethanol (0.54mls, 6.9mmol) and diisopropylethylamine (1.2mls, 6.9mmol) in ACN (20mls) at 30oC for 48 hours. The solvent was evaporated and the residue was purified by silica gel column chromatography with hexane and EtOAc to provide the compound (483mg, 2.7mmol, 59% yield) as a light brown oil. HRMS (ESI, positive) m/z calcd. for C11H18N1O1 [M+H]+: 180.13829, found: 180.13829. 1H NMR (400 MHz, CDCl3) delta 7.28 – 7.19 (t, J = 8.0 Hz, 2H), 6.92 – 6.85 (d, J = 8.2 Hz, 2H), 6.83 – 6.75 (t, J = 7.3 Hz, 1H), 4.03 – 3.88 (hept, J = 6.6 Hz, 1H), 3.70 – 3.62 (t, J = 6.2 Hz, 2H), 3.34 – 3.24 (m, 2H), 1.19 – 1.12 (d, J = 6.6 Hz, 6H).
Statistics shows that 2-Iodoethanol is playing an increasingly important role. we look forward to future research findings about 624-76-0.
Reference:
Article; Bell-Horwath, Tiffany R.; Vadukoot, Anish K.; Thowfeik, Fathima Shazna; Li, Guorui; Wunderlich, Mark; Mulloy, James C.; Merino, Edward J.; Bioorganic and Medicinal Chemistry Letters; vol. 23; 10; (2013); p. 2951 – 2954;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com