Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 160938-18-1, name is 4-Chloro-2-iodo-1-nitrobenzene, A new synthetic method of this compound is introduced below., Formula: C6H3ClINO2
4-chloro-2-iodo-1-nitrobenzene (77.66 g, 274 mmol), 9-phenyl-9H-carbazol- 2- ylboronic acid (157.34 g, 548 mmol), NaOH (5.48 g, After THF / H2O (800 ml / 400 ml) was mixed, Pd (PPh3) 4 (4.36 g, 5 mol%) was added at 40 C At 80 CStir for 12 hours.After completion of the reaction, the reaction mixture was extracted with methylene chloride, and then MgSO 4 was added thereto, followed by filtration to obtain an organic layer. In the obtained organic layer,The residue was purified by column chromatography (Hexane: EA = 3: 1 (v / v)) to give 2- (5-chloro-2-nitrophenyl) -9-phenyl-9H-carbazole (114.8 g, yield 73%).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; DoosanCorporation; Kim, Tae Hyung; Han, Song Eii; Lee, Chang Jun; Sin, Jin Yong; Jo, Hyun Jong; Baek, Young Mi; (56 pag.)KR2015/47858; (2015); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com