Electric Literature of 1437316-91-0,Some common heterocyclic compound, 1437316-91-0, name is 2,4-Difluoro-3-iodoaniline, molecular formula is C6H4F2IN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
N-(2,4-difluoro-3-iodophenyl)propane-l -sulfonamideTo a solution of 2,4-difluoro-3-iodoaniline (255mg, lmmol) in 1,2-dichloroethane (3 mL) was added pyridine (lmL), followed by propane- 1-sulfonyl (157mg, 1. lmmol) and the resulting reaction mixture was heated to refluxing for 2 hrs. The solvent was removed in vacuo. The residue was dissolved in EtOAc, washed with aqueous NaHC03, brine, dried over Na2S04, filtered and concentrated in vacuo to afford the desired product (298mg, 83%>).1H NMR (CDCI3): ? 7.56-7.58 (1H, m), 6.90-6.95 (1H, m), 6.44 (1H, br), 3.03-3.07 (2H, m),1.84-1.90 (2H, m), 1.03-1.07 (3H, m).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2,4-Difluoro-3-iodoaniline, its application will become more common.
Reference:
Patent; CENTAURUS BIOPHARMA CO., LTD.; XIAO, Dengming; LI, Jijun; ZHU, Yan; HU, Yuandong; WANG, Huting; WANG, Zhe; WANG, Zanping; WEI, Yongheng; SUN, Yinghui; WU, Qiong; ZHANG, Hui; PENG, Yong; KONG, Fansheng; SUN, Ying; LUO, Hong; HAN, Yongxin; WO2013/71865; (2013); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com