Application of 3718-88-5, These common heterocyclic compound, 3718-88-5, name is 3-Iodobenzylamine hydrochloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
The intermediate compound prepared in Step 1 (204 mg, 0.32 mmol) and3-iodo-benzylamine hydrochloride (113 mg, 0.41mmol) toIn absolute ethanol (5 mL) under nitrogen gas streamTriethylamine (0.13 mL, 0.96 mmol) was dissolved by stirring at room temperature for 24 hours.Remove the completed residue obtained by concentrated under reduced pressure, the reaction solution after confirming the reaction by column chromatography to intermediate compound (2R, 3S, 4S, 5R) -2- (benzoyloxy-methyl) -5- (2-chloro-6 (3-iodo-benzyl-amino) -9H- purin-9-yl) tetrahydrofuran-3,4-di yl benzoate (230 mg, to obtain a 86.14%).
Statistics shows that 3-Iodobenzylamine hydrochloride is playing an increasingly important role. we look forward to future research findings about 3718-88-5.
Reference:
Patent; Korea University Industry-Academic Cooperation Agency; Kim, Won Gi; Choe, Yong Suk; (44 pag.)KR2015/10195; (2015); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com