Related Products of 97456-81-0,Some common heterocyclic compound, 97456-81-0, name is 1-Bromo-3-iodo-2-methylbenzene, molecular formula is C7H6BrI, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A microwave vial under Ar was charged with ieri-butyl 1-piperazinecarboxylate (154 mg, 0.825 mmol), NaO-i-Bu (95.2 mg, 0.990 mmol), (rac)-BINAP (39.3 mg, 0.0619 mmol, 7.5% mol), Pd2(dba)3 (19.2 mg, 0.0206 mmol, 2.5% mol in Pd), and degassed toluene (2.1 mL). 2-Bromo-6-iodotoluene (121 muL, 0.825 mmol) was then added, and the mixture was heated in sealed vial at 80 C for 19 h, cooled to rt, diluted with CH2CI2, filtered over Celite, and concentrated. The mixture was purified by chromatography on S1O2 (10% EtOAc hexanes) to afford the product as a yellow oil (95 mg, 0.27 mmol, 32%): NMR (500 MHz, CDCI3) delta 7.30 (d, J = 8.0 Hz, 1 H), 7.02 (t, J = 8.0 Hz, 1 H), 6.95 (d, J = 7.5 Hz, 1 H), 3.57 (m, 4 H), 2.83 (t, J = 4.5 Hz, 4 H), 2.40 (s, 3 H),
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Bromo-3-iodo-2-methylbenzene, its application will become more common.
Reference:
Patent; UNIVERSITY OF PITTSBURGH – OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION; WIPF, Peter; SKODA, Erin, M.; WANG, Zhou; WO2015/42297; (2015); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com