Adding a certain compound to certain chemical reactions, such as: 5471-81-8, name is Methyl 4-iodo-3-methylbenzoate, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5471-81-8, Product Details of 5471-81-8
Under a protective atmosphere of inert gas, Pd(OAc)2 (2.2 mg, 10 mol%), XPhos (19.1 mg, 20 mol%), NBE-CO2K (3.5 mg, were added to a 4.0 mL reaction flask equipped with a magnetic stir bar. 10 mol%), methyl 3-methyl-4-iodobenzoate (0.2 mmol, 1.0 equiv.),(4R)-4-((3S,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethylhexadehydro-1H-cyclopenta[a]phenanthrene- 17-yl)pentanoic acid (0.6 mmol, 3.0 equiv.) and dry N-methylpyrrolidone (1.0 mL).The reaction flask was capped and stirred at room temperature for about 5 minutes, after which the mixture was heated to 80 C and stirred 24hour. After the reaction mixture was cooled to EtOAc EtOAc EtOAc m. Purified by column chromatography, the eluent was toluene: diethyl ether = 2:1 (v/v),(2R)-7-Methyl-2-(((4R)-4-((3S,8R,9S,10S,13R,14S,17R)-10,13-dimethylhexadecahydro-3) -Hydroxy-1H-cyclopentadieno[a]phenanthrene-17-yl)pentanoyl)oxy)methyl)-2,3-dihydrobenzofuran-5-carboxylic acid methyl ester 99 mg (colorless oily liquid) ,Yield 85%).
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Reference:
Patent; Wuhan University; Zhou Qianghui; Wu Chenggui; Cheng Honggang; (20 pag.)CN108329285; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com