Electric Literature of 160938-18-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 160938-18-1, name is 4-Chloro-2-iodo-1-nitrobenzene, This compound has unique chemical properties. The synthetic route is as follows.
The obtained from step-1 5- (4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) -1H-indole 22 g (90.5 mmol) and 4-chloro-2-iodo -1-nitrobenzene 28.2 g of purified water was added to 250 mL and dioxane 500 mL (100 mmol).Pd (PPh3) 45.2 g (4.5 mmol), K2CO338 g (271 mmol) was added and the mixture was heated under reflux for 12 hours at 120 .Allowed to cool to room temperature and quench the reaction with 500 mL aqueous solution of ammonium chloride to the reaction mixture.Extract the mixture with EA 500 mL, and washed with distilled water.The resulting organic layer was dried over anhydrous MgSO4,and evaporated under reduced pressure to obtain the desired compound 19.7 g (80% yield) was purified by silica gel column chromatography.
The chemical industry reduces the impact on the environment during synthesis 4-Chloro-2-iodo-1-nitrobenzene. I believe this compound will play a more active role in future production and life.
Reference:
Patent; DoosanCorporation; Sim, Jae Uii; Lee, In Hyuk; Baek, Young Mi; Sin, Jin Yong; Park, Ho Chul; Lee, Chang Jun; Lee, Uhn Jung; Kim, Tae Hyung; Lee, Jae Hun; (35 pag.)KR101571592; (2015); B1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com