Reference of 3058-39-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 3058-39-7 as follows.
General procedure: A 10 mL round-bottom flask was charged with iodobenzene (4a, 1 mmol, 1 eq.), butyl acrylate (5, 1.5 mmol, 1.5 eq.), tributylamine (3 mmol, 3 eq.), H2O (2 mL), and Pd catalyst (0.01 mmol). The flask was stirred at 90 C in air. The reaction was monitored by thin layer chromatography (TLC) and gas chromatography (GC). After the reaction was complete, the reaction mixture was cooled to room temperature and then simply filtered to recover the catalyst. It was then washed with 10mL of H2O and ethyl acetate (EtOAc). The organic phase was separated from the aqueous phase, which was extracted three times with 30 mL EtOAc. The organic phases were collected together, dried over MgSO4, and filtered. The solvent was then evaporated under reduced pressure. Pure product was obtained via silica gel column chromatography with an eluent of EtOAc and hexane. The resulting product was analyzed by 1H NMR spectroscopy.
According to the analysis of related databases, 3058-39-7, the application of this compound in the production field has become more and more popular.
Reference:
Article; Lee, Yongwoo; Hong, Myeng Chan; Ahn, Hyunseok; Yu, Jeongmok; Rhee, Hakjune; Journal of Organometallic Chemistry; vol. 769; (2014); p. 80 – 93;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com