Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 170112-66-0, name is 3,4,5-Trifluoroiodobenzene, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 170112-66-0
Set up a reflux reaction device and put a stirrer into the reaction bottle. 4-propylbiphenylacetylene, 1,2,6-trifluoro-4-iodobenzene, Catalyst Pd(Pph3)4 and cuprous iodide; Replace the air in the sealing system with argon; inject triethylamine, Tetrahydrofuran, stir and slowly heat to reflux. Make sure the system reacts under argon protection. After 7 hours, the degree of reaction was measured by TLC. Step 2), purify the crude product of step 1) with a cable extractor: After the reaction is completed, the reaction solution is poured into ice water, and dilute hydrochloric acid is added dropwise and stirred. Drip into weakly alkaline; extract the above liquid with dichloromethane, collect the organic phase, The organic phase is washed twice with brine and then dried over anhydrous sodium sulfate or anhydrous magnesium sulfate Dry, finally, rotary evaporation of the dry organic phase to give a brown solid. At this time, the brown solid is the crude product of the sonoshihira reaction. Contains target products, self-coupling by-products, and other by-products. Set up the extraction device and pour it in the extraction bottle of the Soxhlet extractor. Into petroleum ether; the brown solid is placed in a filter paper tube, Place the filter paper tube in the extraction tube of the Soxhlet extractor; Heat and reflux for 1-2 hours, and cool the petroleum ether of the extraction bottle to room temperature or lower. The product solid precipitated and was filtered using a suction device. A product having a purity of 95% or more is obtained.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 170112-66-0.
Reference:
Patent; Shenzhen Chao Duowei Technology Co., Ltd.; Zhang Guoxian; Bao Rui; (18 pag.)CN106398714; (2018); B;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com