Some common heterocyclic compound, 19099-54-8, name is 1-Iodo-2-isopropylbenzene, molecular formula is C9H11I, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: iodides-buliding-blocks
Specific operation: In a 25 mL reaction flask equipped with a magnetic stirrer, a metal catalyst palladium acetate (6.7 mg, 0.03 mmol), triphenylphosphine (20.0 mg, 0.075 mmol,) was added,S-2-bromophenyl-S-methyliminosulfanone (70.0 mg, 0.3 mmol), norbornene (56.4 mg, 0.6 mmol), potassium carbonate (82.8 mg, 0.6 mmol), nitrogen protection (at least three times nitrogen cycle)Acetonitrile (3 ml) and 2-iodoisopropylbenzene (88.6 mg, 0.36 mmol) were successively added under a stream of nitrogen.Closed container.The reaction was heated to 80 C for about 24 h, and the reaction was complete by TLC. After the first treatment, the reaction solution was diluted with 15 ml of ethyl acetate.Then, the catalyst and alkali and other inorganic substances are removed by suction filtration through a sand funnel containing silica gel.The resulting filtrate was separated by flash column chromatography to give the pure product 7-isopropyl-5-methyldibenzo[c,e][1,2]thiazine-5-oxide compound 3c.Yield: 40%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 19099-54-8, its application will become more common.
Reference:
Patent; Jiangxi Normal University; Chen Zhiyuan; Zhou Hao; Wang Xiumei; (17 pag.)CN107987034; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com