Application of 112671-42-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 112671-42-8 name is 4-Bromo-1-iodo-2-nitrobenzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Intermediate M2-b (4.8 g, 15 mmol), 2-iodo-5-bromonitrobenzene (5.9 g, 18 mmol), sodium tert-butoxide (2.9 g, 30 mmol), toluene 50 mL, nitrogen, 0.17 g Pd2 Dba) 3, tri-tert-butylphosphine (11 ml, 10% in toluene), openStir, heat to 100 C reflux, reaction 12h, the reaction liquid was washed, the organic phase was concentrated, passed through a silica gel column, the eluent was petroleum ether: ethyl acetate = 50:1, concentrated eluent, to obtain intermediate M2-c ( 6.6 g, yield 84.6%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Bromo-1-iodo-2-nitrobenzene, and friends who are interested can also refer to it.
Reference:
Patent; Beijing Dingcai Technology Co., Ltd.; Gu’an Dingcai Technology Co., Ltd.; Fan Hongtao; Xing Qifeng; Zhang Xianghui; Ren Xueyan; (38 pag.)CN108276428; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com