In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 645-00-1, name is 1-Iodo-3-nitrobenzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 1-Iodo-3-nitrobenzene
General procedure: In a typical reaction, a mixture of alkyne (1.1 mmol), aryl halide(1.3 mmol), amine (2 mmol), catalyst (10 mg, 0.9 mol% of Pd)were added in water (4 mL) and stirred at 70 C for required time.After completion of the reaction (monitored by GC-MS at differenttime intervals) it was cooled to room temperature and the catalystwas separated by simple centrifugal precipitation. The filtrated wasdiluted with water and extracted with 15 mL acetic acid. To obtainthe desired product the organic phase was washed with brine(2 x 10 mL) and dried over anhydrous Na2SO4, then filteredand evaporated under reduced pressure. The products were isolatedby silica gel column chromatography using hexane as eluent.The FT-IR and 1H NMR data of isolated products were comparedwith previously reported literature [26,27]. To check the reusabilityof the catalyst, the recovered catalyst was dried overnight at 100 C and reused in a new coupling reaction under identical conditions.
The synthetic route of 645-00-1 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Gogoi, Rajjyoti; Saikia, Rituraj; Borah, Geetika; Journal of Organometallic Chemistry; vol. 897; (2019); p. 80 – 88;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com