Adding a certain compound to certain chemical reactions, such as: 460-37-7, name is 1,1,1-Trifluoro-3-iodopropane, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 460-37-7, Quality Control of 1,1,1-Trifluoro-3-iodopropane
A solution of 11.3 g (26.2 mmol) of the compound from Ex. 13A in 250 ml DMF was treated with 6.10 g (57.6 mmol) of cesium carbonate and stirred for 15 min at RT.Then 11.7 g (52.3 mmol) 3,3,3-trifluoro-1-iodopropane were added, and the mixture was heated to 70 C.After 6 hours, were further 11.7 g (52.3 mmol) 3,3,3-trifluoro-1-iodopropane added.Stirring at 70 C was continued for 7 hours.After cooling to RT, most of the volatile components was (including DMF) removed on a rotary evaporator.The residue was mixed with 400 ml of ethyl acetate and washed successively with water and saturated sodium chloride solution.After drying the organic phase over anhydrous magnesium sulfate, was filtered and evaporated.The crude product was purified by MPLC on a Biotage cartridge (340 g silica gel, cyclohexane / ethyl acetate 5: 1).The product fractions were combined and evaporated.After stirring of the residue with pentane / dichloromethane (25:1).,Neuerlichem filtration and drying in a high vacuum were obtained 8.78 g (.. 63% of theory) of the title compound
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Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; HAERTER, MICHAEL; DELBECK, MARTINA; KALTHOF, BERND; LUSTIG, KLEMENS; LINDNER, NIELS; KAST, RAIMUND; WASNAIRE, PIERRE; SUESSMEIER, FRANK; (372 pag.)TW2016/7950; (2016); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com